Drought stress is one of the most
critical abiotic factors limiting global crop productivity and sustainability.
Intensified by climate change, recurrent droughts threaten food security and
demand the development of resilient plant varieties. Plant adaptation to
drought involves complex genetic and molecular mechanisms, including water
balance regulation, osmotic adjustment, antioxidant defense, stress-responsive
proteins, and transcriptional control. Key regulators such as DREB, NAC, MYB,
and WRKY transcription factors, together with abscisic acid (ABA) signaling,
aquaporins, and late embryogenesis abundant (LEA) proteins, orchestrate
cellular responses to water deficit. Epigenetic processes—DNA methylation,
histone modifications, and microRNAs—further enhance adaptive flexibility and
establish stress memory. Morphological and physiological traits, including root
system architecture, leaf morphology, photosynthetic stability, and water-use
efficiency, represent phenotypic manifestations of these genetic networks.
Advances in quantitative trait locus (QTL) mapping, genome-wide association
studies (GWAS), and transcriptomics have facilitated the identification of
drought-resistance genes, while marker-assisted selection and CRISPR/Cas9
genome editing offer powerful tools for crop improvement. This review
synthesizes current knowledge on genetic adaptation to drought, highlighting
mechanistic insights and applied strategies. By integrating multi-omics
approaches with modern breeding and biotechnological innovations, future
research can accelerate the development of drought-tolerant cultivars, ensuring
agricultural resilience under changing climatic conditions.
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