Children constitute a distinct patient population in terms of pharmacotherapy due to the dynamic nature of their growth and development processes. The anatomical, physiological, and biochemical changes observed throughout childhood significantly influence drug mechanisms within the organism as well as individual treatment responses. Consequently, this necessitates the adoption of age-appropriate, developmentally tailored, and individualized approaches in the planning, administration, and monitoring of drug therapies in pediatric patients. Pediatric medication administration is a fundamental component of safe and effective healthcare services, holding critical importance in ensuring therapeutic success and mitigating medication-related risks. In this process, healthcare professionals—particularly nurses—bear significant responsibilities in maintaining medication safety. Accurate assessment, effective communication, the adoption of evidence-based practices, meticulous execution of the medication administration process, and systematic monitoring of therapeutic outcomes constitute the core elements of safe medication management. The heightened vulnerability of children to medication errors and drug-related adverse events requires patient safety principles to be prioritized throughout the entire medication management continuum. Safe pediatric medication administration contributes not only to the prevention of medication errors but also to the enhancement of care quality, the reinforcement of patient safety, and the promotion of favorable health outcomes. Therefore, it is an indispensable requirement for healthcare professionals providing care to infants, children, and adolescents to possess up-to-date and comprehensive knowledge regarding pediatric medication practices to deliver high-quality healthcare services.