Empowering Biosensors: The Surface Functionalization Strategies Of Metal Nanoparticles For Enhanced Diagnostics

Yayın Yılı: 2024
Sayfa Aralığı : 111-128
Kitap Dili : İngilizce

This chapter delves into the critical role of metal nanoparticles (MNPs) in biosensor applications, where their unique properties, including high surface area-to-volume ratios, distinctive electronic and optical behaviors, and customizable surfaces, have positioned them as valuable tools across healthcare, environmental monitoring, and food safety diagnostics. The chapter comprehensively explores both chemical and physical methods for surface functionalization, highlighting how these techniques improve MNP stability, reactivity, and biocompatibility. Specific chemical approaches, such as thiol-metal chemistry, silane coupling, carbodiimide chemistry, and maleimide-thiol interactions, enable the robust attachment of biomolecules to nanoparticle surfaces. Physical methods like electrostatic forces, Van der Waals interactions, and polymer coatings offer additional versatility. Advanced techniques, including bioconjugation through the biotin-streptavidin system, aptamer functionalization, and innovative approaches such as Layer-by-Layer assembly and click chemistry, provide enhanced specificity and stability essential for high-performance biosensors. The chapter also examines the technical, regulatory, and scalability challenges that must be addressed to broaden MNP-based biosensor applications, particularly in achieving consistent results across varied environments. By addressing these challenges, MNP-based biosensors have the potential to significantly enhance global public health, environmental sustainability, and food safety.

Kitap Adı: Handbook Of Biosensors Technology
Editor: Sümeyra Savaş
Yayın Yılı: 2024
Sayfa Sayısı: 240
DOI: 10.37609/akya.3400
Kitap Dili : İngilizce
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