Progesteron Tedavisinin Hormon Düzeyleri Ve Solunum Fonksiyonları Üzerindeki Etkileri: Polikistik Over Sendromlu Hastalarda Klinik Bir Çalışma
Anahtar Kelimeler
Objective: This study aimed to investigate the effects of
progesterone treatment on hormone levels and respiratory functions in women
diagnosed with polycystic ovary syndrome (PCOS). PCOS, one of the common
disorders in the endocrine system, can be associated with respiratory problems
due to hormonal imbalances.
Methods: A total of 100 premenopausal women, 50 with PCOS
and 50 healthy controls, were included in the study. The PCOS group was given
10 mg medroxyprogesterone acetate per day for two treatment cycles, while the
control group did not receive any treatment. Hormone levels (FSH, LH, E2) and
lung function parameters (FEV1, FVC, FEV1/FVC, FEF25-75, PEF) were measured
before and after treatment. Data were analyzed using the SPSS 18.0 program.
Results: Following progesterone treatment, significant
improvements in respiratory functions were observed in the PCOS group. These
improvements included increases in FEV1 and FVC values and improvements in
the FEV1/FVC ratio (p < 0.001). Significant changes were also noted in
hormone levels, with decreases in FSH, LH, and E2 levels being associated with
better respiratory outcomes (p < 0.001). No significant difference was found
in lung function between the PCOS and control groups after treatment.
Conclusion: Progesterone treatment effectively improves both
hormonal balance and respiratory function in women with PCOS. However, the
long-term effects of progesterone treatment on respiratory health need to be
investigated with larger samples and longer follow-up studies.
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