Biomolecular Interactions And Surface Chemistry For Biosensors
Biosensors
gain more importance after covid-19 pandemic thanks to their highly selective
and sensitive measurements against for the designed molecule with quite short
response times comparing to modern molecular biological techniques that are used
for diagnosis. Moreover, a well-designed biosensor can perform measurements
that can distinguish the concentrations of the detected target molecules. Here,
the importance of well-modified surface of a sensor comes to play. To be able
to modify a sensor’s electrode surface it is important to know the aspects of
the surface material and its probable interactions. In this chapter, strategies
for immobilizing the biorecognition molecules, and minimizing the non-specific
interactions to enhance the signal transduction will be mentioned. To improve
the stability and the reusability of the sensors there are various modification
techniques that can be perfomed; however, self-assembled monolayers, also known
as SAMs, take the functionality of the biosensors next level by offering
controlable compositions and customizable surfaces at molecular level. Thic
chapter also examines the principles from SAM formation on sensor surface to
SAM modifications for biorecognition element immobilizations.
Kitap Adı:
Handbook Of Biosensors Technology
Atıf Sayısı :
