Idiopathic Inflammatory Myositis

Yazar: Dilek Tezcan
Yayın Yılı: 2025
Sayfa Sayısı: 243-252
Kitap Dili : İngilizce

Idiopathic inflammatory myositis (IIM) is a systemic autoimmune disease with heterogeneous subgroups, mainly characterized by muscle pain and muscle weakness caused by muscle inflammation. IIM diagnoses are based on clinical, laboratory, radiological, electrophysiological, and histopathological findings. IIM can be divided into subgroups in tight of new myositis-specific autoantibodies (MSA), histopathological developments, and classification criteria. These are dermatomyositis (DM), immune-mediated necrotizing myopathy (IMNM), overlap myositis (OM), inclusion body myositis (ICM), amyopathic dermatomyositis (ADM), polymyositis (PM), and cancer-associated myositis. Different subgroups have different clinical, histopathological findings, autoantibody profiles, prognosis, and treatment responses. 30-40% of patients achieve clinical remission with treatment, but 10% have recurrent disease. Mortality is usually due to cardiac (22%), pulmonary complications (22%), infections (15%),and malignancy (11%). IIM is related to an increased risk of heart disease, but the prevalence remains unclear. Approximately 70% of patients may have only subclinical symptoms. The three main causes of cardiac mortality in IIM patients are congestive heart failure, myocardial infarction, and arrhythmias. Evaluation of cardiac function at the time of diagnosis and during follow-up in every patient with myositis is important for early diagnosis and treatment, even in patients with remission.

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